CINTACS

Newsletter of the Cincinnati Section
of
The American Chemical Society

index
Volume 36 - Number 1
October 1998
Editor Ed Burton
Advertising: Jackie Hoofring 
Liaison: Julia Bedell
Advertising Stuart Oehrle

CINTACS is published nine times a year (September through May) by the Cincinnati Section of the American Chemical Society in cooperation with the Oesper Collection in the History of Chemistry of the University of Cincinnati. All changes of address should be sent to Emel Yakali at Raymond Walters College, 9555 Plainfield Road, Cincinnati, OH 45236; 745-5686 or 745-5767 (FAX).

Every member is urged to send in their e-mail address. The message should consist of the e-mail address in the "From" area and the full name of the member in the "Subject" area of the message format. Send this information via e-mail to: ACS@UCRWCU.RWC.UC.EDU
 
 


SUBMISSION DEADLINES


 


The submission deadline for the next Newsletter (November 1998) is Monday, October 5, 1998..

All materials should be sent to:

Dr. Edward Burton, Procter & Gamble, P. O. Box 538707, Cincinnati, OH 45253.
Telephone: (513) 627-1494, FAX: (513) 627-1233, E-mail: burton.de@pg.com

In This Issue ....

Positron Emission Tomography (PET) Studies of Drug Action in the Human Brain

Joanna S. Fowler,
Chemistry Department, Brookhaven National Laboratory

Joanna S. Fowler, Chemistry Department, Brookhaven National Laboratory Positron Emission Tomography (PET) is a medical imaging method which uses radiotracers labeled with short lived positron emitting isotopes to track biochemical transformations as well as the movement of drugs in the living human and animal body. The half lives of the positron emitting isotopes commonly used in PET range from about 1 minute to two hours and they are usually produced on a cyclotron. Some of the commonly used positron emitters are isotopes of the elements of life (for example carbon-11: t1/2: 20.4 minutes and nitrogen-15: t1/2: 10 minutes) and can be incorporated into organic compounds without changing the properties of the parent molecule. Positron emitter labeled radiotracers are produced using rapid synthetic organic chemistry to incorporate simple labeled molecules into more complex labeled organic compounds. The energy emitted from positron decay is detected by a positron emission tomograph which provides images of the regional distribution and kinetics of the radiotracer. PET has emerged as an important scientific tool in the clinical neurosciences where it has been used to address problems in psychiatry, neurology and in the mechanisms of action of therapeutic drugs and drugs of abuse. However, it is advances in rapid synthetic chemistry which have played a key role in these investigations and which will continue to be responsible for advancing knowledge of basic biochemical processes which occur in the living human body and changes which occur in disease. This presentation will focus on studies of psychostimulant drugs.

About The Speaker

Joanna S. Fowler received her B.A. in chemistry from the University of South Florida, Tampa in 1964 and her Ph.D. from the University of Colorado in 1967. After post-doctoral research in organometallic chemistry at the University of East Anglia, England she became a post-doctoral fellow in organic synthesis at Brookhaven National Laboratory. Dr. Fowler is now a senior chemist in the chemistry department at BNL and director of the positron emission tomography (PET) program. Her research includes the synthesis and mechanistic studies of radiolabeled positron-emitting organic molecules and application of these molecules to in vivo studies of neurotransmitter activity, neurodegeneration, and drug metabolism.

Dr. Fowler has received a number of awards including the Jacob Javits Investigator Award in Neurosciences in 1986 and 1993, the American Chemical Society Northeastern Section's Esselen Award for Chemistry in the Public Interest, the Brookhaven National Laboratory R&D Award and, most recently, the Francis P. Garvan-John M. Olin Medal from the American Chemical Society. She has six patents based upon her work and has published over 250 papers.
 
 


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From the Chair


 


Welcome to another yearís activities of the Cincinnati Section of the American Chemical Society. This summer our Section cosponsored a very successful International Conference on Phosphorous Chemistry which set a record for attendance with over 500 participants from 44 countries. On the opening day of the conference we were honored to have former ACS President Helen Free provide a welcoming address to the conferees. Congratulations go to Hal Ebetino for chairing the conference and providing a great kickoff to the International Chemistry Celebration.

Our featured speakers at the monthly meetings this year will provide a variety of interesting topics from archaeology, to brain biochemistry, to applications of bioengineering in the manufacturing of drugs. As in the past, the discussion groups each month will provide additional variety to the meetings. Please note the dates and locations of the monthly meetings listed in this issue of Cintacs and attend as many of the talks and discussion groups as possible.

In addition to the monthly meetings this year will also begin the International Chemistry Celebration (IChC) sponsored by the National ACS. The mission of this celebration is to enhance public appreciation of chemistry and its contributions to everyday life. The Global Salute to Polymers, as part of IChC, will recognize the importance these molecules have in society. More information about IChC can be found at the web site www.chemcenter.org.

A list of the elected officers of the section is included in this issue of Cintacs. Next monthís isssue will have a list of the committee chairs. Both of these will also be available on the Section Web Page (www.che.uc.edu/acs/cinacs.html) along with other activities of the section. Please contact me or any of these individuals to volunteer or offer suggestions.

Sincerely,

Jim Knittel, Chair
College of Pharmacy - University of Cincinnati
james.knittel@uc.edu
 
 


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October Monthly Meeting
Wednesday, October 7
Vernon Manor
Featured Speaker

Joanna S. Fowler,
Chemistry Department, Brookhaven National Laboratory

PROGRAM


 



 
5:30 - 6:15 Discussion Groups
   
Organic: Edward E. Fenlon, Xavier University, "Silatrane-Nucleosides as Transition State Analogues for Phosphoryl Transfer Reactions"
   
Computational: Anping Liu, University of Cincinnati, "Simulations of Phase Equilibria of Ternary Mixtures and Polyelectrolytes by Gibbs Ensemble and MCBMC"
   
6:15 - 6:45 Social Hour (Cash Bar)
   
6:45 - 8:00 Dinner in the Oak Room (cost $22)
  Choice of: Roast Top Sirloin or Chicken Kiev.
  All dinners include: mixed green salad, green beans with shallots, potatoes au gratin, New York cheesecake with berry sauce, iced tea and coffee.
   
8:00
Guest speaker: Dr. Joanna S. Fowler, 
Brookhaven National Laboratories
Positron Emission Tomography (PET) Studies
of Drug Action in theHuman Brain
   
Dinner reservations: Call the section answering line at 558-1224 or email cintacs@uc.edu. Include your name with correct spelling, affiliation, and meun choice. Reservations must be received by Friday, October 2. If you have any difficulties, please call Donna Taylor at 558-0979. As a reminder, if you decide you must miss a meeting after you have made reservations, please call to cancel. If not, the section will have to charge you for the dinner because it will be charged for the dinner.
   
Directions: From all directions follow Reading road to just north of William Howard Taft Rd. Take a left onto Oak Street. The Vernon Manor will be on your right, before you reach Burnet Ave. There is complimentary parking in the Hotel's fenced, secured lot.
   

To reach the intersection of Reading and Oak:


 



 
   
From the south: Take I-471 north to I-71 north and take the Liberty Street exit, just over the I-471 bridge. Turn right off the exit. At the next intersection, take Reading Rd. north. Follow Reading past William Howard Taft Rd and continue as above.
   
From the north: Take I-71 south to the Taft Rd. exit. Turn right onto Reading Rd. and follow above directions.
   
From downtown: Take Columbia Parkway east, turn left onto William Howard Taft Rd. Turn right onto Reading Rd. and follow directions above.

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Nominations Solicited


 






Cincinnati Chemist of the Year

The Section Awards Committee requests nominations for the 1999 Cincinnati Chemist of the Year. This award, given annually since 1950, recognizes professional accomplishments of a member. The 1999 Chemist of the Year will be the featured speaker at the February meeting.

Deadline for nominations is November 18, 1998.

Cincinnati Research Assistant/Technician of the Year

The Section Awards Committee requests nominations for the 1999 Cincinnati Research Assistant/Chemical Technician of the Year. This award, given annually, recognizes job skills, safety, teamwork, leadership, publications and presentations, reliability, communications skills, and additional professional and community activities. A Chemical Technician/Research Assistant is defined as a person whose training includes successful completion of a two year post-high school chemistry curriculum or equivalent work in a Baccalaureate program, or equivalent knowledge gained by experience.

The 1999 award will be presented at the February meeting. The winner will be the section's candidate for the National award.

Deadline for nominations is December 18, 1998.

Nomination forms for each award may be requested from, and returned to:

Henry R. Greeb
Awards Committee Chair
e-Mail: 72277.706@compuserve.com
 
 




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National Chemistry Week - November 1-7, 1998


 






November 1-7, 1998 marks the 11th anniversary of National Chemistry Week (NCW), and the local section plans on celebrating by continuing our library and museum demonstrations. Last year we had demonstrations in over 25 libraries, and the museum center. This year we are starting NCW early with the first demonstrations scheduled for October 27th.

We are looking for newcomers as well as seasoned demonstrators. The demonstrations are easy and fun. Janice Kagermeier, program coordinator of the Hamilton County public libraries, has said that NCW demonstrations are the most popular children's activity the libraries do each year.

Volunteers can get more information on times and locations of the demonstrations by calling Ed and Stephanie Fenlon, 513-745-3361 or 606-331-3564 or email: fenlon@admin.xu.edu or on the section's website: http://www.che.uc.edu/acs/ncw/ncw_cin.html. We plan to have a demonstrator workshop in early October.
 
 


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1998-99 Officers

OFFICE NAME/ADDRESS PHONE NUMBERS
Chair James J. Knittel 
University of Cincinnati 
College of Pharmacy 
3223 Eden Avenue 
Cincinnati, OH 45267-0004
Work: (513) 558-0733 
Fax:(513)558-0978 
e-Mail:James.Knittel@uc.edu
1st Vice Chair
& Chair-Elect
Frank H. (Hal) Ebetino 
Procter & Gamble 
P O Box 8006 
Mason, OH 45040-8006
Work: (513) 622-3630 
Fax: (513) 622-1195 
E-Mail: ebetino.fh@pg.com
2nd Vice Chair Susan Ross 
Department of Chemistry 
University of Cincinnati 
Cincinnati, OH 45221-0172
Work: (513) 556-9207 
Fax: (513) 556-9239 
Email: rossu@email.uc.edu
Secretary Donna Hindman Glaser 
1675 Rudyard Lane 
Cincinnati, OH 45230
Home: (513) 232-8223
Treasurer Hank Greeb 
Hg Consulting, Inc. 
6580 Dry Ridge Rd. 
Cincinnati, OH 45252-1750
Work: (513) 385-8363 
Fax: (513) 385-8888 
Email: 72277.706@compuserve.com
Trustee
(until 6/2001)
William R. Oliver 
Department of Chemistry 
Northern Kentucky University 
Highland Heights, KY 41099-1905
Work: (606) 572-5409 
Fax: (606) 572-5162 
Email: oliver@nku.edu
Trustee
(until 6/2000)
Karlyn A. Schnapp 
Department of Chemistry 
Northern Kentucky University 
Highland Heights, KY 41099-1905
Work: (606) 572-6681 
Fax: (606) 572-5162 
Email: schnapp@nku.edu
Trustee
(until 6/99)
Deanna Ashing 
Designeers MidWest 
4766 Glendale-Milford Rd. 
Cincinnati, OH 45242
Work: (513) 793-6670 
Fax: (513) 793-3616 
Email: ashing@designeers.com
Councilor
(until 12/2001)
Bruce Ault 
Department of Chemistry 
University of Cincinnati 
Cincinnati, OH 45221-0172
Work: (513) 556-9238 
Fax: (513) 556-9239 
Email: bruce.ault@uc.edu
Councilor
(until 12/2001)
Kathy Gibbony 
Procter & Gamble Pharmaceuticals 
P.O. Box 8006 
Mason, OH 45040-8006
Work: (513) 622-2289 
Fax: (513) 622-1433 
Email: gibboney.k@pg.com
Councilor
(until 12/2000)
Roger Parker 
Nobilent, Inc. 
10999 Reed Hartman Hwy. 
Cincinnati, OH 45242
Work: (513) 793-9260 
Fax: (513) 793-9701 
Email: rogparker@aol.com
Councilor
(until 12/1999)
Ted Logan 
8880 Livingston Rd 
Cincinnati, OH 45251-5821 
Home: (513) 385-8856 
Fax: (513) 385-8856 
Email: tjlogancin@aol.com
Alternate Councilor
(1/99-12/2001)
Jim Hershberger 
Department of Chemistry 
Miami University 
Oxford, OH 45056
Work: (513) 529-2441 
Fax: (513) 529-5715 
Email: hershbjw@miami.acs.muohio.edu
Alternate Councilor
(1/99-12/2001)
Dan McLoughlin 
Department of Chemistry 
Xavier University 
Cincinnati, OH 45207
Work: (513) 745-3352 
Fax: (513) 745-1954 
Email: mcloughlin@xavier.xu.edu
Alternate Councilor
(1/99-12/2001)
Tom Ridgway 
Department of Chemistry 
University of Cincinnati 
Cincinnati, OH 45221-0172
Work: (513) 556-9246 
Fax: (513) 556-9239 
Email: thomas.ridgway@uc.edu
Alternate Councilor
(until-12/2000)
Ray D'Alonzo 
Procter & Gamble 
11450 Grooms Road 
Cincinnati, OH 45242
Work: (513) 626-1977 
Fax: (513) 626-5145 
Email: dalonzo.rp@pg.com
Alternate Councilor
(until 12/1999)
Edlyn Simmons 
Hoechst Marion Roussel, Inc. 
2110 E. Galbraith Road 
Cincinnati, OH 45215
Work: (513) 948-7829 
Fax: (513) 948-7961 
Email: edlynsimmons@hmri.com
Auditor
(until 6/2001)
John Shelley 
Procter & Gamble 
Miami Valley Laboratories 
P.O. Box 538707 
Cincinnati, OH 45253-8707
Work: (513) 627-0078 
Fax: (513) 627-1233 
Email: shelley.jc@pg.com
Auditor
(until 6/2000)
Diana McGill 
Department of Chemistry 
Northern Kentucky University 
Highland Heights, KY 41099-1905
Work: (606) 572-6520 
Fax: (606) 572-5162 
Email: mcgill@nku.edu
Auditor
(until 6/1999)
Joe Cantrell 
Department of Chemistry 
Miami University 
Oxford, OH 45056
Work: (513) 529-2834 
Fax: (513) 529-3841

Page updated 1 October 1998. Comments and suggestions to cinacs@www.che.uc.edu