Newsletter of the Cincinnati Section
of The American Chemical Society

Volume 36 - Number 6
March 1999
Editor Ed Burton
Advertising: Jackie Hoofring
Liaison: Julia Bedell
Stuart Oehrle

CINTACS is published eight times a year (October through May) by the Cincinnati Section of the American Chemical Society in cooperation with the Oesper Collection in the History of Chemistry of the University of Cincinnati. All changes of address should be sent to Emel Yakali at Raymond Walters College, 9555 Plainfield Road, Cincinnati, OH 45236; 745-5686 or 745-5767 (FAX).

Every member is urged to send in their e-mail address. The message should consist of the e-mail address in the "From" area and the full name of the member in the "Subject" area of the message format. Send this information via e-mail to:


The submission deadline for the next (April 99) Newsletter is tentatively set for Monday, March 15, 1999. The submission deadline for the May Issue is tentatively Monday, April 12, 1999

All materials should be sent to:
Dr. Edward Burton
Procter & Gamble,

In This Issue ....
From the Chair Meeting Program - March 17
Speaker & topic Discussion Groups
CMAS 2000 Announcement National Awards
Barnes Award Call for Nominations

Chemical Wafare: Past, Present and Future

Dr. Bill White
Edgewood Chemical & Biological Center
Aberdeen Proving Ground


Although the use of chemical weapons dates to antiquity, chemical warfare became a significant concern for military commanders during World War I. The static nature of the conflict, consisting of opposing forces occupying parallel lines, provided the opportunity for toxic gas attacks when the wind was blowing in the desirable direction. The next stage was the use of artillery and aircraft to deliver chemical agents behind the front line. During the 1930's Schraeder, working on new pesticides at I. G. Farben in Germany, discovered that phosphonofluoridates were extremely toxic and thereby created the nerve agent class of CW agents. Like the organophosphorus insecticides, these compounds function by inhibiting acetylcholinesterase. The more toxic V-type agents appeared in the 1950's as a result of other pesticide research.

During World War II, the mobile nature of combat coupled with effective defensive equipment and fear of reprisals reduced the use of chemical weapons. Today, chemical weapons pose a major threat for unprotected civilian populations. Armed forces, who are adequately equipped and trained, should be able to survive a chemical attack with minimal casualties; however, the degradation in performance as a result of operating in protective equipment may reduce effectiveness.

About the Speaker

Bill White received his undergaduate degree in chemistry from Vanderbilt University. After finishing his Ph. D. in organic chemistry from the University of Alabama, he moved to Birmingham and focused his research attention for 11 years on genetic toxicology and mechanisms of enzyme catalysis at the University of Alabama School of Medicine. In 1982, he moved to Edgewood Chemical and Biological Center at the Aberdeen Proving Ground, MD and now heads the research effort to evaluate the hazard to armed forces posed by new chemical and biological warfare agents. His personal research interests center on the use of computational chemistry to study reactions of organophosphorus and organosulfur compounds. In his role as adjunct Professor of Chemistry and Biochemistry at the University of Maryland Baltimore county, he taught a graduate course in "Phosphorus Chemistry" during the spring semester of 1998

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Outstanding Service Award

The Section Awards Committee request nominations for the Outstanding Service Award. This award is to be presented annually to a member of the Section in recognition of outstanding service to the Cincinnati Section and the field of chemistry. Nominees for this award must be members or affiliates of the Cincinnati Section. The 1999 Outstanding Service Award will be presented at the Party Night Section meeting in May. The deadline for nominations is April 1, 1999.

Nominations for this award should be sent to:

Henry R. Greeb
Awards Chair

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From the Chair

At this month’s meeting we will be recognizing the student winners of National Chemistry Week awards. Congratulations to all of the student winners for a job well done. I would also like to thank Rich Sunberg for organizing and administering the contest, and Ed Fenlon for his efforts in organizing a very successful National Chemistry Week for the Section.

Our speaker this month is Dr. William White from the Edgewood Chemical and Biological Center at the Aberdeen Proving Ground, MD. He will be discussing a very timely topic, chemical warfare. I’m sure that this will be a very interesting discussion, especially in light of the recent events in the Middle East and the subway attack in Japan a couple of years ago.

I would like to thank Procter & Gamble for once again hosting our February meeting at the Health Care Research Center. The meeting went well and Bobby Barnett provided us with a very stimulating lecture. Once again I would like to congratulate Bobby for his receipt of the Cincinnati Chemist of the Year Award.

At the February meeting we also honored Ed Cox for his receipt of the National ACS Research Associate of the Year Award. Ed will be receiving his award at the National ACS Meeting in Anaheim. Congratulations Ed!

I am beginning to plan the May Party Night for the section. Any suggestions for locations would be greatly appreciated. Attendance at Party Night has dropped off drastically the past few years and I would find a location that would be pleasing to as many members as possible. Please let me know via email ( if you have any ideas or thoughts on the subject.


Jim Knittel, Chair
College of Pharmacy
University of Cincinnati

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March Monthly Meeting
Wednesday, March 17, 1999
Embassy Suites Hotel
Blue Ash


5:30 – 6:15 Discussion Groups:

Analytical: Oak Room
Organic: Maple Room

6:15 – 7:00 Cocktails in the Atrium
7:00 – 8:00 Dinner, cost $22

Choice of: Chicken Piccata (chicken breast with butter, herbs, and caper sauce)
London Broil (thinly sliced beef with mushroom burgundy sauce)

All dinners include: garden salad, chef’s potato and vegetable, rolls and butter, chocolate mousse, iced tea and coffee

8:15  Dr. Bill White, Edgewood Chemical and Biological Center, Aberdeen Proving Ground

"Chemical Warfare: Past, Present and Future"

Dinner reservations: Call the section answering line at 558-1224 or email Include your name with correct spelling, affiliation, and menu choice. Reservations must be received by Monday, March 15, noon. If you have any difficulties, please call Donna Taylor at 558-0979. As a reminder, if you decide you must miss a meeting after you have made reservations, please call to cancel. If not, the section will have to charge you for the dinner because it will be charged for the it. Payment will be received at the door. Guests are always welcome; emeritus, unemployed, new, and student members are half price.

Directions: Embassy Suites Hotel, 4554 Lake Forest Dr.

From I-71, take exit 15 (Pfeiffer Road exit), head west on Pfeiffer road, two blocks to Reed Hartman Highway. Turn right (north) on Reed Hartman, turn left onto Lake Forest Dr.

From I-275, take the Reed Hartman exit, head south on Reed Hartman about two miles, take a right onto Lake Forest Dr.

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Three Cincinnati chemists/chemical engineers will receive major awards at the 217th ACS National Meeting in Anaheim on March 23.

Gordon F. Brunner, vice president and chief technical officer of Procter & Gamble, will receive the Earle B. Barnes Award for Leadership in Chemical Research Management, sponsored by Dow Chemical. Brunner is being cited for his contributions in three primary areas: project leadership, innovation system improvements, and human resource development. He has been a driving force behind the technical developments of many of P&G’s consumer products, several of which resulted in P&G being awarded the National Medal of Technology in 1995. Besides leading the globalization of the company’s $1.5 billion R&D operations, Brunner has reengineered P&G’s innovation processes to include an Innovation Leadership Team and a Global Technology Council. On the human resources front, Brunner set up a dual-ladder career system, created programs to reward technical achievement, and championed programs to support and advance women and minorities in R&D.

Brunner received a B.S. degree in biochemical engineering from the University of Wisconsin and an M.B.A. from Xavier University. In addition to his ACS membership, Brunner is a director of the Industrial Research Institute and is P&G’s representative on the Council for Economic Development.

A team of scientists from P&G (Manuel Venegas and Michael Showell) and Genencor International (Thomas Graycar, David Estell, and Richard Bott) will receive the ACS Award for Team Innovation, sponsored by Corporation Associates, for their work on recombinant enzymes used in laundry detergents. The P&G/Genencor collaboration, initiated in 1984, is the longest-running industrial collaboration in the history of biotechnology. Beginning with the 1988 introduction of the first recombinant detergent protease to be used in a liquid detergent, the team developed four enzymes that have made their mark in the global liquid and granular laundry detergent markets.

Manuel Venegas received a B.S. degree in chemistry from Loyola University (California) and a Ph.D. in organic chemistry from the University of California, Santa Barbara. At P&G in Cincinnati, he managed the detergent-enzyme program from 1983 to 1992. In addition to the protease work with Genencor, his team began the technology work that led to Carezyme, the first alkaline-active, single-protein cellulase for laundry use. Venegas is currently on international assignment, leading product development efforts for P&G’s laundry business in Latin America.

Mike Showell, currently an associate director at P&G’s Miami Valley Laboratories, received a B.S. degree in chemistry from Willamette University and a Ph.D. in physical chemistry from Purdue University. He joined P&G in 1984 at the Ivorydale Technical Center, where he developed data showing that proteases could deliver broad consumer benefits and worked with Genencor to map out a protein-engineering strategy to optimize these benefits.

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The Cincinnati Section of The American Chemical Society


Name: _______________________________________________________________

Organization: _______________________________________________________________

Department: ______________________________________________________________

Address of Organization: ______________________________________________________________


County: ____________ State:____________________________________ Zip Code:____________

Name and Title of Official Certifying Organizational Compliance with the Grant:

Signature ______________________________________________________________

Name/Title (print or type) _______________________________________________________________

ACS Member or Affiliate? ___________

How many individuals will benefit from this grant if your proposal is funded? ___________

Grant criteria: Funds are to be used to improve chemical education in the area served by the Cincinnati Section of the American Chemical Society.

Grant Proposal: The proposal should contain 300-500 words, double-spaced on official letterhead. It should describe the objective(s) of the project, how the project will be carried out, how the project would improve chemical education, how the program fits into the education program (if the applicant is from a school) and whom would benefit. Also, the proposal should contain a detailed budget which outlines expenditures, the amount being requested from the Educational Grant and the amount being requested from other sources.

Send five (5) copies of the application and the proposal to: Ginger Tannenbaum, Fairfield High School, 8800 Holden Blvd. Fairfield, OH 45014

Reports: Grant recipients are required to submit a report to the Committee within one year from the time of notification of the award. The report will include an outline of how the funds were used, what had been purchased, if anything, with the funds and what benefits have been derived thus far from the use of the funds.

Acknowledgment: It is requested that the major instruments purchased with the use of these funds be tagged with the following acknowledgment: "This equipment was purchased (in part) with an Educational Grant from the Cincinnati Section of the American Chemical Society."

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CMACS 2000 Volunteers Wanted

Link to:

On May 16-19, 2000, the Section will host the 32nd Central Region ACS Meeting (CMACS 2000). Excellent progress is being made towards planing for the meeting. The meeting will take place at the new Northern Kentucky Convention Center. Sessions for the technical program are two-thirds complete. Five Regional awards will be presented and our web site ( is in the final stages of construction. Committee Chairs are listed below. Please contact one of these chairs if you would like to help in a particular area. Additional technical session chairs are needed. Some vacant committee chairs are also listed. If you would like to chair one of these committees please contact Ray D’Alonzo, .
General Chair Ray D’Alonzo Vice General Chair Roger Parker
Finance Chair Tim Cassady Development Chairs Emel Yakali (Academia) 

Kevin Ashley (Industry/Gov.)

Technical Program Chair Al Pinhas Regional Awards Chair Ted Logan
Short Courses/Workshops Chair Joe Kaczvinsky Arrangements Chair Kathy Gibboney
Publicity & Printing Chair Al Hoffman Registration Chair Rajiv S. Soman
Social Program Chair Donna Hindman Glaser H.S. Education Program Chair Ed Escudero
Student Housing Dan McLoughlin Exhibitors Linda Tobeson

Vacant Committee Chair Positions

Chemical Technicians Program
Employment Clearing House
Student Affiliate Program

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Earle B. Barnes Award for Leadership in Chemical Research Management

Industrial R&D: Challenges and Successes
A Symposium presenting topics of importance to the industrial research enterprise

217th ACS National Meeting
Tuesday Afternoon, March 23, 1999
Disneyland Pacific Hotel, Pacific D

Long the largest research-based industry in the world, the chemical industry is reinventing itself. A recent Committee for Economic Development report highlights reasons why reinvention is necessary, including the importance of effective interactions between research universities and their industry partners, and the benefits of the globalization of research. This Symposium will describe important policy-based issues that are affecting the global chemical industry, illustrate the importance of effective university-industry interactions, and offer perspective on projectable trends that will impact research in the future.
1:40-2:10 p.m. Basic Research: Long-term problems facing a long-term investment
George H. Conrades, Polaris Venture Partners
A summary of the findings and recommendations concerning America’s Basic Research Enterprise, based on a study by the Committee for Economic Development
2:10-2:45 p.m. Evolution of the cooperative research paradigm
Christopher T. Hill, George Mason University
A history of cooperative research efforts between industry and academe, including new issues that challenge R&D performers, managers, and policy makers 
2:45-3:15 p.m. Olestra: Inventing the fat-free future
John C. Peters, The Procter & Gamble Company
A review of the chemistry, development, and testing of this new zero calorie fat—an example of internal industrial innovation 
3:15-3:45 p.m. Award Address. Guideposts to the future: Globalizing industrial innovation
Gordon F. Brunner, The Procter & Gamble Company
A discussion of the challenges involved in globalizing R&D and creating a network of interactive laboratories, including the benefits that globalization provides the corporation and the U.S. economy 
3:45-4:15 p.m. Topologically constrained ultra-stable transition-metal complexes for catalysis
Daryle H. Busch, University of Kansas
The development of new catalysts for the activation of dioxygen, peroxides, and peracids based on lipoxygenase modeling—an example of academic innovation sponsored by industry


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